| Tipo de Actividad | Curso/Seminario/Workshop |
| Area(s) de interés | VIDA Biología, Ecología, y Medioambiente
SALU Salud |
| Denominación | Workshop "The cell biology behind the ONCOGENIC PIP3 LIPIDS" |
| Fecha Inicio | 15/10/2018 | Fecha Finalización | 17/10/2018 |
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| Lugar de celebración | Baeza - Jaén - España |
| URL | http://www.unia.es/biomedicine |
Observaciones
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This workshop belongs to the series "Current Trends in Biomedicine", organized by the Universidad Internacional de Andalucía at the Sede Antonio Machado of Baeza (Andalusia, Spain).
More information and application at http://www.unia.es/biomedicine
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Resumen
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The high incidence of mutations in the Phosphoinositide 3-kinase pathway in cancer (in 50% of the human tumors) has posed hope on the use of pharmacological inhibitors to PI3K as a treatment for cancer. Clinical testing of Phosphoinositide 3-kinase-directed compounds has proven that simple blockade of the Phosphoinositide 3-kinase family members by the use of pan-inhibitors is not an optimal therapeutic approach. We have learned that total inhibition of this route promotes undesired secondary effects. Second, in many tumour types, cells develop alternative strategies. Finally, in many cases, the cells develop rapidly resistance. In some tumour types, however, the use of compounds for this pathway has extended life expectation. These facts show the urgent need of a deeper knowledge on the cell biology behind the oncogenic PIP3 lipids (the products of PI3K). This is the topic of our conference, a good starting point for the discussion between experts of a more subtle and rational...
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