| Tipo de Actividad | Curso/Seminario/Workshop |
| Area(s) de interés | VIDA Biología, Ecología, y Medioambiente
SALU Salud |
| Denominación | Workshop “Chaperones in the maintenance of cellular proteostasis” |
| Fecha Inicio | 17/10/2016 | Fecha Finalización | 19/10/2016 |
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| Lugar de celebración | Baeza - Jaén - España |
| URL | http://www.unia.es/biomedicine |
Observaciones
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This workshops belongs to the series "Current Trends in Biomedicine", organized by the Universidad Internacional de Andalucía (UNIA) at the Campus Antonio Machado (Baeza, Spain).
More information and application at http://www.unia.es/biomedicine
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Resumen
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Molecular chaperones comprise a large group of proteins originally characterized as involved in assisting the folding of many proteins. However, it has become clear that their roles are much more complex and diverse, including disaggregation of aggregated species and targeting for protein degradation, among other activities. Molecular chaperones have been extensively studied at the structural and biochemical levels and their cellular role as main proteostasis regulators is well supported. Growing evidence revealing that alterations in cellular quality control underlie the pathogenic basis for severe common human neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases, has brought molecular chaperones back to stardom in recent years. In fact, the tight functional interactions between molecular chaperones and the cellular systems involved in protein clearance, such as the ubiquitin-proteasome system and autophagy, have unveiled chaperones as essential components of the...
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